中老年消化系肿瘤患者血清C反应蛋白与各肿瘤标志物联合检测的临床意义

Diagnostic value of combined detection of serum C-reactive protein and tumor markers in elderly patients with gastrointestinal tumors

目的:探讨C反应蛋白(C-reactive protein,CRP)及各肿瘤标志物(tumor marker,TM)单项或两两联合检测在中老年消化系肿瘤患者中的诊断价值及其临床意义.方法:检测79例中老年消化系肿瘤患者血清CRP及癌胚抗原(carcino-embryonic antigen,C E A)、糖类抗原125(serum antigen 125,CA125)、糖类抗原19-9(serum antigen 19-9,CA19-9)、甲胎蛋白(alpha fetoprotein,AFP),计算各单项指标及两两联合后的灵敏度、特异度或符合率,用SPSS19.0进行统计分析,结合临床得出结论.结果:中老年消化系肿瘤患者CRP、CEA、C A19-9、C A125、A F P测定值均高于正常对照组(P<0.05);CRP、CEA、CA19-9、C A125、A F P对中老年消化系肿瘤的灵敏度分别为:64.56%、26.58%、49.37%、37.97%、12.70%;各指标之间两两联合检测,CRP与CA19-9灵敏性最高,为82.10%,CRP与CEA、CA125、AFP联合检测的敏感性分别为73.98%、78.00%、67.30%.结论:CRP对于消化系肿瘤的早期发现有一定临床意义,CRP与TM联合检测,对中老年消化系肿瘤的检测有很好的互补性.

AIM：To investigate the diagnostic value of C-reactive protein（CRP） and tumor markers in elderly patients with gastrointestinal tumors.METHODS：CRP,carcino-embryonic antigen（CEA）,antigen 125（CA 125）,antigen 19-9（CA19-9）,and alpha-fetoprotein（AFP）were detected in 79 elderly gastrointestinal tumor patients and 30 healthy controls.The diagnostic sensitivity and specificity of these indexes,alone or combination of any two,were calculated.RESULTS：Serum levels of CRP,CEA,CA19-9,CA125,and AFP in gastrointestinal tumor patients were significantly higher than those in the normal control group.The sensitivities of CRP,CEA,CA19-9,CA125,and AFP were64.56%,26.58%,49.37%,37.97%,and 12.70%,respectively.The sensitivities of combined assay of CRP and CEA,CRP and CA125,and CRP and AFP were 73.98%,78.00%and 67.3%,respectively,which were higher than those of any single tumor markers.CONCLUSION：The detection of CRP,combined with other tumor markers,plays an important role in the early diagnosis of gastrointestinal tumors in elderly patients.