河南省不同人群HCV感染相关因素分析

Hepatitis C infection status and its influencing factors among several types of population in Henan province

目的了解影响河南省不同人群丙型肝炎病毒（HCV）感染的相关因素。方法采取多阶段抽样的方法,在全省抽取1~75周岁的常住居民开展问卷调查和静脉血采集,并对不同人群的感染相关因素进行分析。结果共调查河南省普通人群32 203人,标化后HCV抗体阳性率是0.64%。HCV感染水平在年龄组和城乡人群的差异有统计学意义。经年龄分层分析,有偿采供血史[比值比（OR）=15.16]、输血史（OR=7.44）、文身（OR=2.53）、使用血液制品史（OR=2.42）、手术史（OR=2.32）和非一人一针一管注射行为（OR=1.93）,是18岁及以上成年人感染HCV的危险因素,但对18岁以下儿童则无统计学意义。经城乡分层分析,穿耳洞、内窥镜检查和针灸、刮痧仅对城镇居民感染HCV有统计学意义,而使用血制品史仅对农村居民有统计学意义。结论 18岁以下儿童HCV感染水平低,与加强血液安全管理、实施安全医疗注射等措施有关。建议加强城镇居民远离不健康的生活方式,到正规医疗机构就医的教育,增加丙型肝炎防治知识的学习。

Objective To explore the related factors associated with hepatitis C virus infection among several types of population in Henan province.Methods A multi-stage sampling was used to investigate general population aged 1-75 years old living in different districts.Questionnaires were administrated and blood samples were collected to analyze hepatitis C virus infection status and its influencing factors.Results Among the general population,the overall prevalence rates of anti-HCV was 0.64%.The prevalence rates of anti-HCV in urban and rural population,and different age groups were statistically significant.Results through stratified analysis showed that related factors among HIV-infected persons older than 18 years including history of paid plasma donation（OR=15.16）,blood transfusion（OR=7.44）,tattooing（OR=2.53）,using blood products（OR=2.42）,operation（OR=2.32）,and needle-sharing behavior（OR=1.93）.Stratified analysis between urban and rural population,ear-piercing,endoscopic examination,acupuncture or Gua Sha were related factors for urban population,while using blood products was related factor for rural population.Conclusion Children younger than eighteen years with low level of HCV infection was associated with strengthening blood safety management and implementing of medical injection safety.It was necessary to disseminate knowledge of prevention and treatment of hepatitis C,and advocate a healthy lifestyle in order to reduce HCV transmission.