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苯达莫司汀单药治疗难治性霍奇金淋巴瘤完全缓解1例并文献复习 被引量:1

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摘要 霍奇金淋巴瘤(Hodgkin's lymphoma,HL)的年轻患者逐渐增多,80%以上的HL经单纯化疗或化疗联合放疗可获得完全缓解。然而,经一线治疗后,15%~20%的患者原发耐药或复发。目前,对于复发或难治性霍奇金淋巴瘤的治疗仍是一项巨大的挑战。苯达莫司汀(bendamustine)是一种兼具烷化剂和抗代谢作用的双功能氮芥衍生物,已广泛用于非霍奇金淋巴瘤、多发性骨髓瘤、慢性淋巴细胞白血病等血液肿瘤和乳腺癌等实体肿瘤的治疗,其疗效确切,不良反应小,安全性高。本文报告1例难治性HL患者,经苯达莫司汀单药治疗后完全缓解。
作者 宋腾 王华庆
出处 《癌症进展》 2015年第4期454-456,共3页 Oncology Progress
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