摘要
目的 通过观察牙周机械治疗慢性牙周炎患者治疗前及治疗后不同时间点龈沟液疱疹病毒检出率的变化,分析慢性牙周炎与疱疹病毒的关系,并且为牙周炎患者的治疗及预后提供一个微生物学依据.方法 随机选取2012年3月-2014年3月来我院口腔科进行牙周机械治疗的慢性牙周炎患者16例,采用巢式聚合酶链反应分别检测患者治疗前、治疗后2个周、2个月、4个月时点龈沟液中的巨细胞病毒（HCMB）和EB病毒1型（EBV-1）,并分析两种病毒检出率的变化情况.结果 慢性牙周炎患者HCMB、EBV-1治疗前检出率分别为43.8％、15％,治疗后2个周时HCMV、EBV-1的检出率降至最低,分别为8.8％、0;治疗后2个周、2个月、4个月时HCMV和EBV的检出率均明显低于治疗前（P＜0.05）,HCMV在治疗后2个月的检出率（15％）比2周时（8％）有所回升,差异无统计学意义（P＞0.05）.结论 疱疹病毒在慢性牙周炎患者的发病中起一定作用,并且在牙周机械治疗后2个月内临床指标最为敏感,可以在治疗2周后复查以指导临床治疗.
Objective To observe the detection rate changes of herpes virus at different time points of periodontal mechanical treatment in patients with chronic periodontitis gingival crevicular fluid and analyze the relationship between chronic periodontitis and herpes virus,which provide a means of microbiological basis for the treatment and prognosis of patients with periodontitis.Methods 16 patients with chronic periodontitis periodontal mechanical treatment of cases were randomly selected as research subjects between March 2012-March 2014 in the department of stomatology in our hospital.HCMB） and EB virus type 1 （EBV-1） were detected in gingival crevicular fluid of cytomegalovirus by nested polymerase chain reaction before and after treatment for 2 weeks,2 months,4 months time and analysis of the changes in the incidence of two kinds of virus.Results HCMB and EBV-1 positive rates were respectively 43.8%,15% for the patients with chronic periodontitis before treatment.HCMB and EBV-1 detection rate were respectivly 8.8%,0 after 2 weeks of treatment.There was significantly difference between before treatment and after 2 weeks of treatment,after 2 months and 4 months treatment （P 〈 0.05）.Conclusions Herpes virus plays a certain role in the pathogenesis of chronic periodontitis patients and periodontal machinery.The clinical index of the most sensitive time in 2 months after treatment.
出处
《国际病毒学杂志》
2015年第4期250-252,共3页
International Journal of Virology
关键词
牙周炎
机械治疗
巨细胞病毒
EB病毒
Chronic periodontitis
Mechanical treatment
Cytomegalovirus
EB virus
