摘要
目的观察阿托伐他汀钙联合不同剂量别嘌醇对高脂血症患者血尿酸(UA)及血脂水平的影响。方法 90例高脂血症伴高尿酸血症患者随机分为三组:A组(常规剂量别嘌醇治疗)、B组(小剂量别嘌醇+阿托伐他汀治疗)及C组(常规剂量别嘌醇+阿托伐他汀治疗),各30例。治疗4周后比较三组患者治疗前后的血尿酸和血脂的变化及不良反应。结果治疗4周后三组血尿酸均显著下降,其中B、C组均比A组下降更明显,差异有统计学意义(P<0.05)。A组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)轻度下降,与治疗前比较,差异有统计学意义(P<0.05),B、C组TC、TG、LDL-C显著下降,与治疗前比较,差异有统计学意义(P<0.05)。治疗4周后,B组与C组血脂及血尿酸指标相比较,差异无统计学意义(P>0.05)。结论阿托伐他汀钙联合别嘌醇能更有效改善高脂血症患者的血脂水平,同时具有降低尿酸作用,而联合小剂量别嘌醇即可达到良好治疗效果。
Objective To observe influence of atorvastatin combined with different doses of allopurinol on blood uric acid（UA） and blood lipid in hyperlipemia patients. Methods A total of 90 hyperlipemia complicated with hyperuricemia patients were randomly divided into three groups, as group A（conventional dose of allopurinol treatment）, group B（small dose of allopurinol ＋ atorvastatin treatment） and group C（conventional dose of allopurinol treatment＋ atorvastatin treatment）, with 30 cases in each group. Changes of blood uric acid and blood lipid, adverse reactions were compared in the three groups after 4 weeks of treatment. Results All groups had remarkably decreased blood uric acid after 4 weeks of treatment, and groups B and C had much decreased blood uric acid than group A. Their difference had statistical significance（P〈0.05）. There was statistically significant difference of decreased total cholesterol（TC）, triglyceride（TG）, low density lipoprotein cholesterin（LDL-C） in group A before and after treatment（P〈0.05）. TC, TG, and LDL-C in groups B and C were obviously decreased after treatment, and their difference had statistical significance（P〈0.05）. After 4 weeks of treatment, the differences of blood lipid and blood uric acid between groups B and C had no statistical significance（P〈0.05）. Conclusion Combination of atorvastatin and allopurinol can effectively improve blood lipid and reduce uric acid in hyperlipemia patients. Atorvastatin combined with small dose of allopurinol can provide excellent effect in treatment.
出处
《中国实用医药》
2015年第22期8-10,共3页
China Practical Medicine
