氯吡格雷联合低分子肝素钙治疗急性多发性脑梗死的疗效观察

Observation of curative effect by clopidogrel combined with low molecular weight heparin calcium in the treatment of acute multiple cerebral infarction

目的探讨氯吡格雷联合低分子肝素钙治疗急性多发性脑梗死的疗效。方法 88例急性多发性脑梗死患者随机分为对照组(43例,采用肠溶阿司匹林、胞二磷胆碱治疗)和治疗组(45例,采用氯吡格雷、低分子肝素钙、胞二磷胆碱治疗)。对比两组疗效。结果治疗组总有效率高于对照组(P<0.05);治疗后血液流变学改善优于对照组(P<0.05)。结论氯吡格雷联合低分子肝素钙治疗急性多发性脑梗死具有协同作用,有明显控制病情发展作用。

Objective To investigate curative effect by clopidogrel combined with low molecular weight heparin calcium in the treatment of acute multiple cerebral infarction. Methods A total of 88 acute multiple cerebral infarction patients were randomly divided into control group（43 cases, received enteric-coated aspirin and citicoline for treatment） and treatment group（45 cases, received clopidogrel, low molecular weight heparin calcium and citicoline for treatment）. Curative effects of the two groups were compared. Results The treatment group had higher total effective rate than the control group（P〈0.05）, and its hemorheological improvement was better than the control group after treatment（P〈0.05）. Conclusion Combination of clopidogrel and low molecular weight heparin calcium contains synergistic effect in treating acute multiple cerebral infarction, and this method can effectively control the progression of disease.