利巴韦林与干扰素联合治疗手足口病的临床观察

Clinical Efficacy of Ribavirin plus Interferon for Hand-foot and Mouth Disease

目的:观察利巴韦林与干扰素联合治疗手足口病的临床疗效。方法:将80例手足口病患儿以随机数字表法分为2组各40例,治疗组患者给予利巴韦林与干扰素联合治疗,对照组患者给予利巴韦林单药治疗,对比观察2组患儿的临床治疗效果及病毒学改变情况。结果:治疗组患者临床总有效率为95.00%(38/40),明显高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);治疗组患儿发热缓解时间、皮疹萎缩时间、口腔溃疡愈合时间、治愈时间、48及72 h后病毒学应答情况均优于对照组,差异有统计学意义(P<0.05)。结论:利巴韦林与干扰素联合治疗手足口病,可有效缓解疱疹和溃疡等症状,加速退热,较利巴韦林单药治疗具有更好的病毒学效果和临床疗效,值得临床推广。

OBJECTIVE： To evaluate the efficacy of ribavirin plus interferon for hand-foot and mouth disease.METHODS： 80 children with hand-foot and mouth disease were randomly assigned to receive either ribavirin plus interferon（ treatment group） or ribavirin alone（ control group） of 40 cases each. The curative efficacy and virology change in the two groups were followed. RESULTS： The clinical total effective rate in treatment group was significantly higher than in the control group[95. 0%（ 38 /40） vs. 80. 0%（ 32 /40）,P〈0. 05]. The treatment group was better than the control group regarding the time to fever relief,shrinking of skin rash,oral ulcer healing,cure time and virological response in 48 and 72 hours（ P〈0. 05）. CONCLUSIONS： Ribavirin in combination with interferon can effectively relieve the symptoms of herpes and ulcers,facilitate pyretolysis in children with hand-foot and mouth disease,exhibiting better virological and curative efficacy than ribavirin alone,thus the combined use of the two drugs is worthy of clinical recommendation.