胃癌患者围术期胃肠激素及Th1/Th2指标的变化研究

Change of gastrointestinal hormones and Th1/Th2 indexes of patients with gastric cancer during the perioperative period

目的：研究胃癌患者围术期胃肠激素及Th1／Th2指标的变化情况。方法：选取2013年10月～2014年10月进行手术治疗的45例胃癌患者为观察组，并选取同时期体检健康的45名同龄人员为对照组，然后将观察组术前1d，术后1d、3d、7d及14d的血清胃肠激素及Th1／Th2指标和对照组的进行分别检测与比较。结果：观察组术前1d、术后1d、3d、7d及14d的血清胃肠激素水平均差于对照组（P均d0．05），而术前1d及术后1d、3d及7d的血清Th1／Th2指标也均差于对照组（P均〈0．05），且观察术后3d的血清胃肠激素及Th1／Th2指标明显差于其他时间（P均〈0．05）。结论：胃癌患者围术期胃肠激素及Th1／Th2指标的波动较大，应根据其波动情况给予针对性干预。

Objective： To study the change of gastrointestinal hormones and Thl/Th2 indexes of patients with gastric cancer during the perioperative period. Methods： A total of 45 patients with gastric cancer who were treated with operation in our hospital from October 2013 to October 2014 were selected as observation group,45 healthy persons who received health ex- amination at the same time as the control group. The serum gastrointestinal hormones and Th1/Th2 indexes of observation group were detected on the first day before the operation and on the first, third, seventh and fourteenth day after the operation. Results： The serum gastrointestinal hormones of observation group on first day before the operation and on the first, third, seventh and fourteenth day after the operation were all significantly worse than those of control group （P〈0.05） ; the serum Th1/ Th2 indexes on the first day before the operation and on the first, third and seventh day after the operation were all significantly worse than those of control group （P〈0.05）. The serum gastrointestinal hormones and Th1/Th2 indexes of observation group on the third day after the operation were significantly worse than those at other time （P〈0. 05）. Conclusion： The fluctuation of gastrointestinal hormones and Thl/Th2 indexes of patients with gastric cancer during the perioperative period are large. And targeted intervention should be performed according to the fluctuation situation.