过氧化苯甲酰联合多磺酸黏多糖对寻常痤疮患者血清性激素水平、免疫指标的影响

Effect of benzoyl peroxide combining with Hirudoid on serum sex hormone levels,immune index of patients with acne vulgaris

目的:观察过氧化苯甲酰联合多磺酸黏多糖对寻常痤疮患者血清性激素水平、免疫指标的影响。方法:将185例纳入研究的重度寻常痤疮患者抽签分为观察组(85例)和对照组(80例),观察组给予过氧化苯甲酰联合多磺酸黏多糖外用治疗,对照组仅给予过氧化苯甲酰,治疗2个月,观察性激素(T、FSH、LH、E2)及免疫指标(IgG、IgA、IgM、C3、C4、IL-2、sIL-2R)的变化。结果:观察组治疗后IgG、C3、C4、IL-2与本组治疗前比较下降明显,差异有统计学意义(P<0.05),对照组所有指标变化不明显,差异无统计学意义(P>0.05);两组治疗后IgG、C3、C4、IL-2水平比较,差异均有统计学意义(P<0.05)。两组治疗前后性激素各指标比较,差异均无统计学意义(P>0.05)。结论:过氧化苯甲酰联合多磺酸黏多糖方案对寻常痤疮患者的免疫功能有一定的影响,治疗作用可能也与此有关,但对性激素无明显影响。

Objective： To observe the effects of benzoyl peroxide combining with Hirudoid on serum sex hormone lev- els, and immune index of patients with acne vulgaris. Methods： A total of 185 patients with acne vulgaris including in the study of patients were divided into observation group （85 cases） and control group （80 cases）, observation group was given the treat- ment of benzoyl peroxide combining with Hirudoid, the control group was treated with benzoyl peroxide, Observed the change of hormones （T, FSH, LH, E2） and immune indexes （IgG, IgA, IgM, C3, C4, IL-2, slL-2R） after I month of treatment. Results： After treatment, IgG, C3, C4, IL-2 of observation group were significantly decreased compared with that before treatment （P〈0.05）, but no significant difference in these indexes were observed in the control group （P〈0.05）. After treatment, IgG, C3, C4, IL-2 level of two groups were statistically significant （P〈0.05）. While there were no significant difference in sex hormones between the two groups before and after treatment. Oorlclusion： Benzoyl peroxide combining with Hirudoid has certain effects on immune function for the patients with acne vulgari which might be the mechanism of its thera- peutic effect, but it has no obvious effect on sex hormone levels.