骨形态发生蛋白15及雌激素受体1基因多态性与卵巢早衰关系Meta分析

BMP15 and ESR1 gene polymorphism and POF: a meta-analysis

目的 探讨骨形态发生蛋白15（BMP15）及雌激素受体1（ESR1）基因多态性与卵巢早衰（POF）发生的关系。方法 采用Meta分析方法,计算机检索MEDLINE、PREMEDLINE、Cochrane Library、中国期刊全文数据库（CNKI,1994-01-2012-03）等,收集有关病例对照研究或队列研究,由两位研究者独立进行文献筛选、资料提取和方法学质量评价后,采用Rev Man 5.3和Stata12.0软件进行Meta分析。结果 共纳入16个研究。Meta分析结果显示,BMP15-9C〉G,788ins TCT,852C〉T,308A〉G及ESR1 Pvull,Xbal多态性,POF组与对照组相比差异无统计学意义（P〉0.05）。BMP15538G〉A突变发生POF风险增加,是正常人的6倍以上,且结果差异有统计学意义（AA＋AG vs.GG：OR 6.33,95%CI2.04~19.62,P=0.001;A等位基因vs.G等位基因：OR 8.96,95%CI 2.53~31.74,P=0.0007）。结论 BMP15-9C〉G,788ins TCT,852C〉T,308A〉G及ESR1 Pvull,Xbal多态性与POF发病无关,BMP15 538G〉A多态性与POF发病可能相关。

Objective To research the relationship between BMP15 and ESR1 gene polymorphism and premature ovari- an failure. Methods The databases such as MEDLINE, PREMEDLINE, Cochrane Library, CNKI database were searched to collect case-control or cohort studies for the comparison. The quality of the retrieved trials was critically ap- praised. Meta-analyses were conducted using RevMan 5.3 and Statal2.0 software respectively.Results A total of 16 studies were included. The result of meta-analyses showed：there were no significant differences （P〉0.05） between the two groups for BMP15 -9C〉G, 788insTCT, 852C〉T, 308A〉G and ESR1 Pvull, Xbal gene polymorphism. BMP15 538G〉 A mutation significantly increased the risk of POF, more than six times than controls （AA＋AG vs. GG：OR 6.33,95%CI 2.04-19.62, P=0.001 ; A vs. G： OR 8.96,95%CI 2.53-31.74, P=O.0007）.Conclusion BMP15 -9C〉 G, 788insTCT, 852C〉 T, 308A〉 G and ESR1 Pvull, Xbal polymorphism is irrelevant to POF;BMP15 538G〉 A polymorphism may be as- sociated with POF.