慢性肾炎患者TNF-α及IL-6的表达及临床意义

The expression and clinical significance of serum TNF-α and IL-6 in patients with chronic nephritis

目的检测慢性肾炎患者治疗前后TNF-α、IL-6的水平,探讨其与肾损伤的相关性。方法采用酶联免疫法对72例慢性肾炎患者治疗前后TNF-α、IL-6、24 h尿蛋白水平进行检测,并同时对30例健康者行TNF-α、IL-6、24 h尿蛋白检测。结果慢性肾炎患者治疗前TNF-α和IL-6、24 h尿蛋白水平较对照组显著升高,差异有统计学意义(P<0.05);治疗后TNF-α和IL-6、24 h尿蛋白水平较治疗前明显降低,差异有统计学意义(P<0.05);经pearson相关性分析显示,治疗前后TNF-α、IL-6与24 h尿蛋白均呈明显正相关(P<0.05)。结论慢性肾炎患者体内存在TNF-α及IL-6水平的异常,观察TNF-α及IL-6水平的变化对了解慢性肾炎患者病情及观察疗效均有重要的临床价值。

Objective To detect the concentration of TNF-α and IL-6 in patients with chronic nephritis,explore its correlation with kidney damage. Methods The 24 h urine protein,serum TNF-α,IL-6 of 72 patients with chronic nephritis were measured before and after treatment by using enzyme linked immunoassay and compared with these with that of 30 healthy people. Pearson correlation analysis was used to study the correlation between TNF-α,IL-6 and 24 h urine protein. Results The TNF-α,IL-6 and 24 h urine protein were significantly higher than healthy control（ P〈0. 05）. After the treatment,the levels of TNF-α,IL-6 and 24 h urine protein were significantly decreased（ P〈0. 05）. The levels of TNF-α and IL-6 were positively correlated to 24 h urine protein（ P〈0. 05）. Conclusions Serum levels of TNF-α and IL-6 in patients with chronic nephritis are abnormal,levels of TNF-α and IL-6 can be used as a parameter for evaluating treatment effect and monitoring relapse.