脑梗死患者淀粉样前体蛋白和β-微管蛋白的表达及预后研究

Expression and prognosis in patients with cerebral infarction blood precursor protein and β-tubulin

目的：检测淀粉样前体蛋白（APP）和β-微管蛋白在脑梗死患者血清中的表达，为临床诊断治疗提供参考。方法选取88例急性脑梗死患者血液标本（观察组），取健康人血液标本30例（对照组），应用酶联免疫吸附实验（ELISA）检测 APP 和β-微管蛋白的表达，分析其与不同临床特征之间的关系。结果观察组 APP（168．78±13．64）μg／L，β-微管蛋白（124．64±27．08）μg／L，均显著高于对照组（t ＝22．81、21．08，均P ＜0．01）；APP 和β-微管蛋白的表达与脑梗死患者的梗死范围及预后密切相关。结论APP 和β-微管蛋白在脑梗死患者中高表达，联合检测 APP 和β-微管蛋白可能对判断预后及指导治疗有临床意义。

Objective To investigate the expressions of amyloid precursor protein and β-microtubule protein,and to study their clinical significance in patients with cerebral infarction.Methods 108 cases of acute cere-bral infarction as the observation group and 60 normal adults as the control group were collected in the study.The expressions of amyloid precursor protein and β-microtubule protein in different clinical characters were detected by western blot.Results The results of observation group [APP：（168.78 ±13.64）μg/L,β-tubulin：（124.64 ± 27.08）μg/L]were significantly higher than those in control group （t =22.81,P 〈0.01;t =21.08,P 〈0.01）.Their expressions were correlated with CT scores and prognosis.Conclusion The higher expressions of amyloid precursor protein and β-microtubule protein may promote the occurrence and development in patients with cerebral infarction. The joint detection should be helpful to predict the prognosis and direct the treatment.