摘要
目的:探讨非黄嘌呤类腺苷阻断剂 SLV320对慢性心衰(CHF)动物实验模型心室重构及肾素-血管紧张素-醛固酮系统(RAAS)的影响。方法将40只普通级成年雄性新西兰兔予以阿霉素静脉注射建立CHF 模型,再按照随机原则分为:高剂量组,予以静脉注射 SLV320剂量为10.0μg·kg -1·d -1;中剂量组,剂量为5.0μg·kg -1·d -1;低剂量组,剂量为2.5μg·kg -1·d -1;呋塞米组,予以灌服呋塞米2.0 mg·kg -1· d -1。每组均为10只,连续用药1周。检测并比较实验前后四组的血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、B 型钠尿肽(BNP)水平;检测并比较实验前后四组左室收缩末内径(LVESD)、左室舒张末内径(LVEDD)、左心室后壁厚度(LVPW)、左心射血分数(LVEF)、左室缩短分数(LVFS)、E /A 等心室功能指标;准确称重左心室及右心室,计算并比较四组左心室重量指数(LVWI)和右心室重量指数(RVWI)。结果实验前四组血浆 PRA、AngⅡ、ALD、BNP 水平差异无统计学意义(P >0.05),实验后四组各指标水平顺序为:高剂量组<中剂量组<低剂量组<呋塞米组(均 P <0.05)。实验前四组各心室功能指标差异无统计学意义(P >0.05),实验后 LVEF 及 LVFS 指标顺序为:高剂量组>中剂量组>低剂量组>呋塞米组(均P <0.05),而LVESD、LVEDD、LVPW、E /A 指标顺序为:高剂量组<中剂量组<低剂量组<呋塞米组(均 P <0.05)。治疗后 LVWI 及 RVWI 顺序为:高剂量组<中剂量组<低剂量组<呋塞米组(均 P <0.05)。结论SLV320能改善 CHF 的心室重塑及 RASS 系统,且具有剂量依赖性。
Objective To analyze the effect of non -xanthine adenosine receptor antagonist (SLV320)on the ventricular remodeling and renin -angiotensin -aldosterone system (RAAS)in animal experimental models of chronic heart failure (CHF).Methods The 40 healthy male New Zealand rabbits were received adriamycin by intra-venous injection to establishing the experimental animal models and were randomly divided into 4 groups,which were high -dosage group (injected with SLV320,10.0μg·kg -1 ·d -1 ),medium -dosage group (injected with SLV320, 5.0μg·kg -1 ·d -1 ),low -dosage group (injected with SLV320,2.5μg·kg -1 ·d -1 )and furosemide group (fed with furosemide,2.0mg·kg -1 ·d -1 ).Each group had 10 rabbits and continuous treated for one week.The indexes of plasma renin activity (PRA),angiotensinⅡ (AngⅡ),aldosterone (ALD)and beta ntriuretic peptide (BNP)were detected at pre -and post -treatment,and compared among 4 groups.The indexes of left ventricular end -systolic dimension (LVESD),left ventricular end -diastolic dimension (LVEDD),left ventricular posterior wall (LVPW), left ventricle ejection fraction (LVEF),left ventricular fractional shortening (LVFS)and E /A at pre -and post -treatment were detected by echocardiography and compared among 4 groups.The wet weigh of the left and right ventri-cle were weigh accurately.And the indexes of left ventricle weight index (LVWI)and the body weight index (BWI) were calculated and compared among 4 groups.Results The plasma levels of PRA,AngⅡ,ALD and BNP were no different among 4 groups before study (all P 〉0.05).The sequence of 4 groups on the plasma levels of RAAS indexes was high -dosage group 〈medium -dosage group 〈low -dosage group 〈furosemide group (all P 〈0.05).The ven-tricular function indexes were no different among 4 groups before study (all P 〉0.05).The sequence of 4 groups on the levels of LVEF and LVFS was high -dosage group 〉medium -dosage group 〉low -dosage group 〉furosemide group,and the sequences of LVESD,LVEDD,LVPW and E /A were high -dosage group 〈medium -dosage group 〈low -dosage group 〈furosemide group (all P 〈0.05).The sequences of 4 groups on the LVWI and RVWI were high-dosage group 〈medium -dosage group 〈low -dosage group 〈furosemide group (all P 〈0.05 ).Conclusion SLV320 can regulate the ventricular remodeling and RAAS in animal model of CHF and this effect was dose dependent.
出处
《中国基层医药》
CAS
2015年第16期2457-2460,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
非黄嘌呤类腺苷阻断剂
心力衰竭
心室重构
肾素-血管紧张素-醛固酮系统
Non -xanthine adenosine receptor antagonist
Heart failure
Ventricular remodeling
Renin -an-giotensin -aldosterone system