中西医结合治疗 Barrett 食管44例近期及远期疗效分析

Effectiveness of combination of traditional Chinese medicine and western medicine therapy for patients with barrett esophagus

目的：探讨中西医结合治疗 Barrett 食管的近期、远期疗效及复发情况，为中西医结合治疗Barrett 食管提供理论依据。方法将44例 Barrett 患者采用随机数表法随机分为对照组与观察组，在质子泵抑制剂抗酸治疗方案的基础上，给予对照组内镜下氩离子凝固术治疗，给予观察组中药方剂联合内镜下氩离子凝固术治疗，分别于治疗结束后3个月、6个月、12个月及18个月观察并比较两组有效率及复发率。结果观察组在治疗结束后3个月、6个月、12个月及18个月治疗总有效率分别为100．00％、100．00％、94．74％及93．33％，均显著高于对照组的95．45％、90．48％、84．21％及81．25％（χ2＝4．71、3．55、7．28、5．10，均 P ＜0.05）；在治疗后6个月、12个月及18个月复发率分别为0．00％、10．53％及13.33％，12个月及18个月的复发率均显著低于对照组的21．05％、31．25％（χ2＝5．84、6．51，均 P ＜0．05）。结论中西医结合治疗 Barett 食管疗效肯定，复发率低，值得临床推广。

Objective To explore effectiveness of combination of traditional Chinese medicine and western medicine therapy for patients with Barrett esophagus （BE）.Methods Patients with BE were divided into the control group and observation group according to random number table.The observation group was received treatment of com-bination of argon plasma coagulation （APC）and traditional Chinese medicine,while the control group was received treatment of APC alone.Clinical effectiveness was observed at 3,6,12,18months after treatments,recurrence rate was observed 6,12,18months after treatments.Results Clinical effectiveness were significantly higher in the observation group than in the control group 3,6,12,18months after treatments （χ2 =4.71,3.55,7.28,5.10,all P 〈0.05）. Recurrence rate were significantly lower in the observation group than in the control group 6,12,18 months after treat-ments （χ2 =5.84,6.51,all P 〈0.05）.Conclusion Combination therapy of traditional Chinese medicine and west-ern medicine shows confirmed effects to BE.Low recurrence rate in addition makes it become a promising clinical therapy in treatment of BE.