LOX-1、CX3CR1与冠状动脉狭窄性疾病PCI手术前后的关系

Association of the LOX-1 and CX3CR1 levels with coronary artery stenosis disease before and after PCI operation

目的探讨血凝素样氧化低密度脂蛋白受体-1(LOX-1)、CX3C趋化因子受体1(CX3CR1),对经皮冠状动脉介入治疗(PCI)前后冠状动脉狭窄病变的评估作用及应用价值。方法 80例行PCI手术的冠状动脉狭窄疾病患者(病例组)在术前、术后1 d^3 d和术后30 d^60 d及40例对照组均空腹采集静脉血测定LOX-1、CX3CR1水平。记录2组的一般资料及实验室指标,应用SPSS 17.0软件进行统计分析。结果 PCI术后1 d^3 d LOX-1、CX3CR1开始明显下降,到术后30 d^60 d其水平均低于术前及对照组水平。经Logistic回归及ROC曲线分析表明,LOX-1是PCI术前、术后1 d^3 d冠脉狭窄病变的危险因素,并且具有一定的诊断效力。结论 LOX-1、CX3CR1与PCI前后冠状动脉狭窄病变关系密切,可用于PCI术后冠状动脉病变的评估,从而对PCI术后冠状动脉病变的预防及治疗发挥作用。

Objective To explore evaluation function and application value of lectin- like oxidized low- density lipoprotein receptor- 1（ LOX- 1） and CX3 C chemokine receptor 1（ CX3CR1） to the coronary artery stenosis disease before and after percutaneous coronary intervention（ PCI）. Methods A total of 80 patients with coronary artery stenosis which had received PCI（ case group） and forty healthy volunteers（ control group） were collected venous blood to detect LOX- 1,CX3CR1 level before and after PCI 1 d- 3 d and after PCI 30 d- 60 d. The general information and laboratory parameters were recorded in the 2groups. All of the data were statistically analyzed by SPSS 17. 0 software. Results LOX- 1 and CX3CR1 levels began to decline significantly in 1 d- 3 d after PCI and were averagely lower in 30 d- 60 d post PCI than that in before PCI and in control group,respectively. Logistic regression and receiver operating characteristic（ ROC） curve analysis showed that LOX- 1 levels before PCI,level of LOX- 1 in 1 d- 3 d after PCI were risk factors of coronary artery stenosis lesion,and there were some diagnostic efficiency of coronary artery stenosis lesion. Conclusion LOX- 1 and CX3CR1 are closely related to coronary artery stenosis lesion before PCI and after PCI,can be used for assessment of coronary artery lesions after PCI,and in this way come into play for prevention and treatment of coronary artery lesion after PCI.