DAB2IP和β-catenin在胃癌中的表达及其临床意义

Expressions of DAB2IP and β-catenin in gastric carcinoma and its clinical significance

目的探讨DAB2IP和β-连环蛋白(β-catenin)在胃癌组织中的表达及其与临床病理因素的关系,分析DAB2IP和β-catenin蛋白之间的相关性。方法应用免疫组化En Vision法检测70例胃癌组织和20例相应癌旁组织中DAB2IP和β-catenin的表达,并对胃癌患者临床病理资料进行分析。结果 DAB2IP蛋白在胃癌和癌旁组织中的阳性表达率分别为47.14%和90.00%,两者比较差异有统计学意义(P<0.05)。β-catenin蛋白在胃癌组织中的阳性表达率为71.42%,高于癌旁组织的0.00%,差异有统计学意义(P<0.05)。DAB2IP和β-catenin蛋白表达在胃癌患者临床分期、浸润深度及淋巴结是否转移间的差异有统计学意义(P<0.05),而与患者年龄、性别、肿瘤大小及分化程度无关(P>0.05)。胃癌中DAB2IP和β-catenin蛋白表达呈负相关(P<0.05)。结论胃癌组织中DAB2IP表达下调,β-catenin表达升高,且二者表达呈负相关,DAB2IP和β-catenin异常表达与胃癌临床分期、浸润和转移有关。

Objective To study the expression of DAB2 IP and β- catenin in gastric carcinoma and its relationship with clinical and pathological factors,and analyze the relationship between DAB2 IP and β- catenin protein. Methods The expressions of DAB2 IP in 70 cases of gastric carcinoma and β- catenin in 20 cases of corresponding para- carcinoma gatric mucosa tissues were detected by immunohistochemical En Vision method,and the clinical and pathological data of gastric carcinoma were analyzed. Results The positive rates of DAB2 IP protein in gastric carcinoma tissues and para- carcinoma gastric tissues were47. 14% and 90. 00%,respectively,and the difference between them was statistically significant（P〈0. 05）. The positive rate of β- catenin protein in gastric carcinoma tissues was 71. 42%,which was higher than that of para- carcinoma gatric tissue（ 0. 00%）,and the difference had statistical significance（P〈0. 05）. The expressions differences of DAB2 IP and β- catenin protein among clinical stage,infiltration depth and lymph node metastasis were statistically significant（P〈0. 05）,but were not correlated with age,sex,tumor size or the degree of differentiation（P〈0. 05）. Expression of DAB2 IP was negatively associated with expression of β- catenin in gastric carcinoma（P〈0. 05）. Conclusion In gastric carcinoma,down- regulation of DAB2 IP and up- regulation of β- catenin,are in a negative correlation. Abnormal expression is correlated with clinical stage,invasion and metastasis.