摘要
目的:探讨不同严重度分级的慢性阻塞性肺疾病急性加重期(AECOPD)患者血浆v WF水平及意义。方法:对24例对照组、21例I、Ⅱ级AECOPD、21例Ⅲ级AECOPD、44例Ⅳ级AECOPD血浆v WF水平进行检测。结果:各级AECOPD患者血浆v WF水平显著高于对照组(P<0.05),不同严重度分级的AECOPD患者血浆v WF水平均存在显著差异(P<0.05)。结论:血浆v WF水平增高提示血管内皮细胞损伤及功能失调,AECOPD患者存在血管内皮细胞损伤及功能失调,对治疗及预后存在不利影响。
Objective： To investigate the levels and significance of vWF in patients with acute exacerbations of chronic obstructive pulmonary disease（ AOCEPD）. Methods： The levels of vWF in 24 patients in the control group,21 cases I / Ⅱ,21 cases Ⅲ,and 44 cases Ⅳ AECOPD were detected. Results： The plasma levels of vWF in patients of AECOPD were significantly higher（ P〈0. 05） than that of control groups,futher,there was a significant（ P〈0. 05） difference of m WF levels among different classification of severity in patients with AECOPD. Conclusion： The increased levels of plasma vWF prompt endothelial cell injury and dysfunction,which will cause adverse effects on the treatment and prognosis of AECOPD patients.
出处
《广州医科大学学报》
2015年第1期79-81,共3页
Academic Journal of Guangzhou Medical University
