摘要
目的:探讨血浆白细胞介素(IL-17)在慢性阻塞性肺疾病(COPD)综合评估中的作用。方法:取30例健康体检者(健康对照组)、按照GOLD2011综合评估标准入选COPD ABCD级患者各30例,采用双抗体酶联免疫吸附测定(ELISA)法测定血浆中IL-17水平。并对全部研究对象进行肺功能检查,计算出一秒钟用力呼气容积占用力肺活量比值(FEV1%/FVC)及进行CAT问卷评分。结果:COPD各级别血浆IL-17水平及CAT评分与正常对照组存在统计学差异,除A级和B级,B,C,D各级两两之间及CAT评分再各级别两两之间均存在统计学差异(P<0.05),且随着级别的恶化两指标水平总体上呈上升趋势。各级别血浆IL-17水平与CAT评分均存在正相关。结论:血浆IL-17水平可作为COPD患者综合评估的全身炎症水平严重程度指标。
Objective： To investigate the role of interleukin-17（ IL-17） in the comprehensive evaluation of the chronic obstructive pulmonary disease（ COPD）. Methods： The serum levels of IL-17 was determined by double antibody enzyme-labeled immunosorbent assay（ DA-ELISA） in 30 healthy control and 30 COPD patients from stage A to stage D. Pulmonary functions of all research subjects were tested and calculated for the percentage of forced expiratory volume in one second（ FEV1） of prediction value（ FEV1%）. Results： The level of serum IL-17 and the score of AQ20 questionnaire in COPD group,no matter pulmonary infection,is higher than the control group. There are statistical significant（ P〈0. 05）. Among various stages of COPD,except between stage A and stage B the level of serum IL-17,the level of serum IL-17 and the score of CAT questionnaire,there are statistical significant（ P〈0. 05）.And with stage raised,the level gradually increases. various the level of serum IL-17 of COPD is positive correlation with the score of CAT questionnaire,Conclusion： The serum levels of IL-17 can be used as the relevant indicators of inflammatory indices in the comprehensive evaluation of the COPD.
出处
《广州医科大学学报》
2015年第2期97-100,共4页
Academic Journal of Guangzhou Medical University
