我院抗菌药物实行分级管理后使用情况分析

Using Condition Analysis on Classification Management of Antibiotics

目的:分析抗菌药物分级管理干预措施的实施及效果。方法:选择2011年5月至2013年5月间我院全院出院患者6622例的病案资料。其中实施分级管理制度之前的患者3238例,实施分级管理制度之后的患者3384例,分析分级管理前后医院抗菌药物使用情况。结果:实施分级管理制度后抗菌药物使用率,人均使用频次及人均抗菌药物费用均明显降低,与实施分级管理制度前比较差异具有统计学意义(P<0.05)。实施分级管理制度后一线抗菌药物使用率显著提高,二线、三线抗菌药物使用率降低,与实施分级管理制度前比较差异具有统计学意义(P<0.05)。实施分级管理后三联用药比例显著降低(P<0.05),送检标本及检出阳性率较实施分级管理前无统计学意义(P>0.05)。结论:实施抗菌药物分级管理可以有效的限制抗菌药物滥用情况,对于临床抗菌药物合理应用有积极意义。

Objective： To analyse the implementation and effect of intervention measures in the classification management of antibiotics （CMA）. Methods： The medical records of 6622 discharged patients, admitted to Xuzhou Tumor Hospital from May 2011 to May 2013, were collected, and then the 6622 discharged patients were divided into the patients （n=3238） treated before the implementation of CMA and the patients （n=3384） treated after the implementation of CMA. The using conditions of antibacterial drugs in the hospital were analysed before and after the implementation of CMA. Results： Compared with before the implementation of CMA, usage of antibacterial drugs, per capita use frequency and per capita cost of antimicrobial agents were significantly decreased after the implementation of CMA, with statistically significant differences （P〈0.05）; The first line antibiotics use rate significantly increased, but the second and the third, decreased after the implementation of CMA, with statistically significant differences （P〈0.05））. Triple drug ratio significantly decreased （P〈0.05）, after the implementation of CMA, there was no statistical significance in the samples and the positive rates compared with before the implementation of CMA （P〉0.05）. Conclusion： The implementation of CMA can effectively limit the abuse of antibiotics, which have positive significance for the clinical reasonable application of antibacterial drugs.