低分子肝素钙联合双抗治疗进展性缺血性脑卒中疗效观察

The clinical effect observation of low molecular weight heparin calcium combined with double anti-therapy in the treatment of progressive ischemic stroke

目的观察低分子肝素钙联合双抗治疗进展性缺血性脑卒中的临床效果。方法将100例进展性缺血性脑卒中患者随机分为观察组和对照组各50例。观察组采用氯吡格雷及拜阿司匹林与低分子肝素钙联合治疗,对照组采用血塞通常规治疗。观察2组患者治疗前后纤维蛋白原(Fg)水平、凝血酶原时间(PT)及神经功能缺损评分变化。结果观察组治疗总有效率为94%高于对照组的70%,差异有统计学意义(P<0.05);2组疗前Fg、PT比较差异无统计学意义(P>0.05),疗后2周,观察组Fg水平低于对照组,PT大于对照组,差异均有统计学意义(P<0.05);治疗前2组患者神经功能缺损评分比较差异无统计学意义(P>0.05),治疗后观察组神经功能缺损评分低于对照组(P<0.05)。结论采用低分子肝素钙联合双抗血小板治疗进展性缺血性脑卒中,可改善神经神经功能缺损情况,提高临床治疗效果,改善脑微循环,对改善患者预后有非常重要的价值。

Objective To observe the clinical effect of low molecular weight heparin calcium combined with double anti-therapy in the treatment of progressive ischemic stroke. Methods 100 patients with progressive ischemic stroke were randomly divided into observation group and control group,50 cases in each. The control group was treated with Xuesaitong intravenous drip treatment; observation group was treated with clopidogrel combined with aspirin and low molecular weight heparin calcium. Before treatment and after two weeks＇ treatement,the level of fibrinogen（ Fg）,prothrombin time（ PT） and neurological function defect in two groups were observed. Results The total effective rate in the observation group（ 94%） was higher than the control group（ 70%）,the difference was statistically significant（ P 0. 05）. Before treatment,the differences of the levels of Fg,PT between the two groups were not statistically significant（ P 0. 05）. After 2 weeks＇ treatment,observation group Fg level was lower than that of control group and PT was higher than control group,the differences were statistically significant（ P 0. 05）. After treatment,the observation group of neural function defect score was lower than the control group（ P 0. 05）. Conclusion Low molecular weight heparin calcium combined with dual antiplatelet in treatment of progressive ischemic stroke can improve the nerve function defect and clinical treatment effect,and improve the cerebral microcirculation,which has very important value to the prognosis of the patients.