腺苷蛋氨酸联合门冬氨酸钾镁治疗小儿重度黄疸性肝炎疗效观察

The clinical effect observation of adenosylmethionine and potassium magnesium aspartate in children with severe jaundice hepatitis

目的观察腺苷蛋氨酸联合门冬氨钾镁治疗小儿重度黄疸性肝炎的疗效。方法将210例小儿重度黄疸性肝炎患者随机分为观察组和对照组各105例。观察组采用腺苷蛋氨酸联合门冬氨钾镁治疗,对照组采用异甘草酸镁治疗,比较2组治疗效果。结果观察组的总有效率为94.3%高于对照组的83.8%,差异有统计学意义(P<0.05)。治疗后观察组各临床症状改善情况优于对照组,差异有统计学意义(P<0.05)。2组患者接受治疗后均无严重不良反应发生。结论腺苷蛋氨酸联合门冬氨钾镁治疗小儿重度黄疸性肝炎能有效改善患者临床体征,疗效较好,不良反应少,值得临床推广。

Objective To observe the clinical effect of adenosylmethionine and potassium magnesium aspartate in children with severe jaundice hepatitis. Methods 210 cases patients with children with severe jaundice hepatitis were randomly divided into observation group and control group,each of 105 cases. Observation group was treated by adenosylmethionine and potassium magnesium aspartate. Control group was treated by magnesium isoglycyrrhizinate. After treatment,compared the clinical effect of 2 groups. Results The total efficiency of observation group（ 94. 3%） was higher than that of control group（ 83. 8%）,the difference was statistically significant（ P 0. 05）. The improvement of clinical symptoms of observation group was better than that of control group,the difference was statistically（ P 0. 05）. There were no no serious adverse events of 2groups. Conclusion Adenosylmethionine and potassium magnesium aspartate in children with severe jaundice hepatitis can effectively improve the clinical signs,as well as has an good effect and less adverse reactions,which is worthy of clinical application.