p38促分裂原活化蛋白激酶在神经病理性疼痛中的作用

The Potential Role of p38 MAPK in the Neuropathic Pain

促分裂原活化蛋白激酶(MAPKs)家族是细胞内重要的信号传导系统,并在神经可塑性以及炎症反应方面发挥重要作用。MAPKs家族包括3个家庭成员:细胞外信号调节激酶、c-Jun氨基末端激酶和p38MAPK。p38 MAPK信号通路是MAPKs家族信号通路的枢纽,诱导多种与神经性病理疼痛相关的细胞内反应。p38 MAPK可以作为神经元和胶质细胞中研究疼痛的靶标,为疼痛性疾病的治疗提供一个潜在治疗方案。

Mitogen-activated protein kinases（MAPKs） mainly included extracellular signalregulated kinas（ERKs） family, the c-Jun NH2-terminal kinases（JNKs） family and p38 MAPKs family. They play a well-recognized role in neural plasticity and inflammatory response. p38 MAPK signal transduction pathway is one of the multiple parallel MAPK signal transduction pathways, involving in the formation and maintenance of pain. p38 MAPK induces a variety of intracellular responses associated with neuropathic pain and other chronic pain. Thus, specific targeting p38 MAPK molecule and its signaling pathway represent potential therapeutic strategies for pain management.