摘要
B7-H3是新近发现的共刺激分子B7家族的一个新成员,在T细胞介导的免疫反应中发挥重要的调节作用。B7-H3蛋白在正常组织、细胞中不表达或极低表达,却高表达于多种实体肿瘤组织,如前列腺癌、肾透明细胞癌、非小细胞肺癌等,并与肿瘤的进展、患者的生存及预后密切相关。本文就常见实体肿瘤中B7-H3的表达情况及临床指导意义作一综述。
B7-H3 is a newly identified member of the B7 superfamily of costimulatory molecules, serving as an accessory modulator of T cell-mediated response. B7-H3 is overexpressed in a variety of different human solid cancers, such as prostate cancer, renal cell carcinoma, non-small cell lung cancer, et al, while generally absent or low expressed in normal human somatic tissues. Besides, B7-H3 expression has also been found significantly correlated with tumor progression, prognosis and survival of patients. This paper reviews on the expression and clinical significance of BT-H3 in common solid tumors.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2015年第9期807-811,共5页
Immunological Journal
基金
国家自然基金面上项目(81173611)
