稳心颗粒对心脏起搏患者早搏的治疗及起搏阈值和心电信号振幅的影响

The effect of Wenxin Granules on pacing threshold and endocardial electrical signal amplitude

目的观察稳心颗粒对起搏器新植入患者起搏阈值、心内电信号振幅的影响。方法新植入双腔起搏器202例患者中,合并房性早搏（简称房早）、室性早搏（简称室早）102例设为观察组,同期未合并房早、室早且与观察组条件相似者100例为对照组,起搏器术后第2-3天观察组给予口服稳心颗粒,每天3次,每次3 g,共计服用60天;对照组未给予抗心律失常药物治疗,观察两组服药前后及起搏器第10、30、60天心房、心室起搏阈值和心内电信号振幅。结果两组60天动态心电图比较,观察组房早、室早60天治疗显效率、有效率明显高于对照组（42.2%vs 26.0%;41.1%vs 29.0%,P均〈0.05）。起搏脉宽为0.4 ms时,用药前;用药后10,30,60天观察组与对照组心房、心室起搏阈值及心房、心室P波、R波振幅两组均无差异（P均〉0.05）。结论口服稳心颗粒有效治疗房早、室早且对急性期起搏阈值及心内电信号振幅无影响。

Objective To observe the effects of Wenxin Granules on pacing thresholds of pacemaker implanted newly and endocardial electrical signal amplitude in patients. Methods Two hundred and two patients who were implanted per- manent pacemaker were recruited. 102 cases in treatment group received oral Wenxin Granules 3. Og/3 times a day in 2-3 days after pacing with rapid atrial arrhythmia, ventricular premature, and 100 matching cases in control group did not re- ceive Wenxin Granules without cardiac arrhythmias. The period was 60 days. Atrial and ventricular pacing thresholds and endocardial electrical signal amplitude were observed before and after giving patients Wenxin Granules and 10,30 and 60 days after pacemaker implanted. Results Wenxin Granules significantly reduced atrial and ventricular premature （effi- cency ：83.3% vs 55.0%, compared with control group）. At 0.4 ms pacing pulse width, there were no significant difference of atrial and ventricular pacing thresholds and P-wave and R wave amplitude at I0,30,60 days between the treatment group and the control group （P〉O. 05）. Conclusion Wenxin Granules can effectively teat the atrial and ventricular prema- ture. Oral Wenxin Granules do not effect the pacing thresholds and the endocardial electrical signal amplitude in 60 days.