三七总皂苷对高血压性脑出血患者血肿吸收及神经功能恢复的影响

Effect of panax notoginseng saponins(PNS)on the absorption of hematoma and neurological function recovery in patients with hypertensive intracerebral hemorrhage

目的观察三七总皂苷(PNS)对高血压性脑出血(HICH)血肿吸收及神经功能恢复的影响。方法将入选的HICH患者120例随机分为PNS组(常规药物治疗加三七总皂苷)58例和对照组(常规药物治疗)62例;所有入选患者分别于入组第1、4、10、17 d利用CT测量血肿体积,并进行神经功能缺损评分(NIHSS)和日常生活活动能力评定(ADL)。对照组采用内科常规脑出血治疗方法,PNS组先采用常规药物治疗3 d,并于第4 d开始加用血塞通注射液(主要成分为PNS)0.4 g静滴,1次/d,连用14 d,于第10 d和第17 d进行疗效判定。结果 PNS组第10、17 d血肿体积均小于对照组(P<0.01);第10 d神经功能缺损评分低于对照组(P<0.05),第17 d神经功能缺损评分低于对照组(P<0.01),日常生活活动能力分值均高于对照组(P<0.01)。结论三七总皂苷能明显促进高血压性脑出血血肿的吸收,促进神经功能的恢复。

Objective To observe the effect of panax notoginseng saponins （PNS） on hematoma absorption and neurological function recovery in patients with hypertensive intracerebral hemorrhage（HICH）. Methods The 120 HICH patients enrolled were randomly divided into two groups, PNS group （conventional drug treatment plus PNS） 58 cases and the control group （conventional drug treatment） 62 cases. Scanning hematoma volume by CT, the National Institutes of Health Stroke Scale （NIHSS） scores and activities of daily living （ADL）, all the three methods were used on the 1st, the 4th, the 10 th and the 17 th day. Conventional medi- cal treatment of cerebral hemorrhage was used in the control group. PNS group were treated with conventional drug therapy for three days, and on the fourth day plus XUESAITONG injection （with the main component of PNS） 0. 4 g infusion, 1 times/d, for 14 days. At the 10 th and the 17 th day, efficacy was determined. Results Hematoma volume of PNS group was less than that of the control group at the 10 th and the 17 th day. Neurological deficit scores were lower, while activities of daily living scores were higher. Conclusions PNS can significantly promote the absorption of hematoma as well as the recovery of neurological function in patients with HICH.