肿瘤坏死因子受体相关因子参与炎症免疫调节的研究进展

Research advance of tumor necrosis factor receptor-associated factors in inflammatory immune regulation

肿瘤坏死因子受体相关因子(tumor necrosis factor receptor-associated factors,TRAF)是一类重要的具有多功能的细胞内信号转导因子。TRAF参与多种受体家族的信号转导,包括肿瘤坏死因子受体家族(tumor necrosis factor receptor,TNFR)和Toll样-IL-1受体(Toll-like receptors-interleukin-1 receptors,TLR-IL-1R)家族等,在固有免疫和获得性免疫中发挥重要作用。受体活化时,TRAF直接或间接募集下游受体的胞内结构域,参与信号转导,最终激活NF-κB和干扰素调节因子(interferon regulatory factor,IRF)等活化转录因子信号通路,从而诱导免疫和炎症反应,参与炎症免疫性疾病的发生发展。

The tumor necrosis factor receptor（ TNF-R）-associated factor（ TRAF） is an important of multifunctional intracellular signal transduction factors. TRAFs involve in signal transduction of many receptor families,including TNF receptor family（ TNFR）,Toll-like receptors interleukin-1 receptors（ TLR-IL-1R）family and so on. TRAFs play important roles in innate immunity and acquired immunity. TRAFs could directly or indirectly recruit the intracellular domains of receptors in the condition of activated receptor,which leads to the activation of transcriptionfactors,such as NF-κB and interferon-regulatory factor（ IRF）,through signaling pathway. And TRAFs ultimately induce immune and inflammatory responses and involve in the development of inflammatory autoimmune diseases.