影响狼疮性肾炎患者并发股骨头坏死危险因素的多元Logistic回归分析

Effect of lupus nephritis multivariate Logistic regression analysis of risk factors in patients with avascular necrosis of the femoral head

目的探讨影响狼疮性肾炎（LN）患者并发股骨头坏死危险因素.方法将2009年8月至2013年8月收治的50例LN患者并发股骨头坏死患者作为观察组,另外选择同期收治的50例LN未并发股骨头坏死患者作为对照组.分别采用Pearson单因素与多元Logistic回归分析的方法,对影响LN患者并发股骨头坏死的危险因素进行分析.结果经Pearson单因素分析,两组患者在口腔溃疡、雷诺现象、血管炎、纤维蛋白原（Fib）升高、总胆固醇（TC）、三酰甘油（TG）水平方面的差异均具有统计学意义（P〈0.05～0.01）;经多元Logistic回归分析,口腔溃疡、雷诺现象、血管炎、Fib升高、TC及TG水平为影响LN并发股骨头坏死的危险因素.结论影响LN患者并发股骨头坏死的危险因素包括口腔溃疡、雷诺氏现象、血管炎、Fib升高、TC及TG水平,在实际治疗过程中应注意针对这些因素采取措施.

Objective To study the effect of lupus nephritis( LN)patients complicated with femoral head necrosis factor risk. Methods Between 2009 August to 2013 August in our hospital,50 cases of LN patients complicated with avascular necrosis of the femoral head of patients were included as the observation group,in addition to selecting 50 cases of avascular necrosis of femoral head without LN patients as control group. Using univariate Pearson and multivariate Logistic regression analysis to analyze the influence on the risk of LN patients with femoral head necrosis. Results The single factor analysis by Pearson,two groups of patients with oral ulcer,Raynaud′s phenomenon,vasculitis,elevated Fib,TC and TG level in terms of the differences were statistically significant( P <0. 05 ~0. 01). By multivariate Logistic regression analysis,oral ulcer, Raynaud′s phenomenon,vasculitis,increased Fib,TC and the level of TG( P <0. 05)are the risk factors for the effect of LN complicated with femoral head necrosis. Conclusion The risk factors for LN patients with avascular necrosis of the femoral head included oral ulcer,Raynaud′s phenomenon,vasculitis,elevated Fib,TC and TG levels. These factors should be paid attention to examine these factors in the actual treatment process.