特布他林联合布地奈德雾化吸入治疗支气管哮喘的疗效及安全性

The effect and safety of terbutaline combined with budesonide inhalation in treating bronchial asthma

目的探讨特布他林联合布地奈德雾化吸入治疗支气管哮喘(哮喘)的疗效及安全性。方法选取2012年12月—2013年12月成都市第三人民医院收治的哮喘患者120例,随机分为治疗组和对照组,各60例。对照组采用常规治疗,治疗组在常规治疗基础上给予特布他林布联合地奈德雾化吸入治疗。比较两组患者呼气流量峰值差值(△PEF),喘息、胸闷、咳嗽、哮鸣音缓解时间和住院时间,患者口咽感染、声嘶、口干、手指震颤例数。结果两组患者△PEF、喘息、咳嗽、哮鸣音缓解时间、住院时间比较,差异有统计学意义(P<0.05),两组患者胸闷缓解时间比较,差异无统计学意义(P>0.05)。两组患者口咽感染、口干、手指震颤例数比较,差异无统计学意义(P>0.05),两组患者声嘶例数比较,差异有统计学意义(P<0.05)。结论特布他林联合布地奈德雾化吸入治疗哮喘是安全、有效的。

Objective To study the effect and safety of terbutaline combined with budesonide inhalation in treating bronchial asthma （asthma）. Methods From December 2012 to December 2013 in the Third Hospital of Chengdu City, a total of 120 asthma patients were selected and randomly divided into treatment group and control group, 60 cases in each group. Control group were treated with conventional therapy, treatment group were treated with terbutaline combined with budesonide inhalation on the basis of conventional therapy, peak expiratory flow difference value （ aPEF）, and the time of wheez remission, chest tightness relief, cough relief, wheeze relief and hospital stay, the cases of oropharyngeal infection, hoarseness, dry mouth, trembling fingers between the two groups were compared. Results The aPEF, wheezing, chest tightness, coughing, wheeze remission time, hospital stay between the two groups were compared, the differences were statistically significant （P 〈 0. 05） ; there was no statistically significant differences in chest tightness relief between the two groups （P 〉 0. 05）. The cases of oropharyngeal infection, dry mouth, trembling fingers between the two groups were compared, the differences were not statistically significant （ P 〉 0. 05 ） ; there was statistically significant differences in cases of hoarseness between the two groups （ P 〈 0. 05）. Conclusion Terbutaline combined with budesonide inhalation are safe and effective in treating asthma.