未足月胎膜早破影响因素研究进展

Progress of influence factors on premature rupture of membranes

未足月胎膜早破(PPROM)是产科常见妊娠并发症之一,对母婴健康具有严重影响,也是导致胎儿死亡的常见病因,其诱发因素比较,发病机制尚未确定,国内外研究认为母体感染、创伤、微量元素缺乏、宫颈功能及胎儿发育等多种因素有关,近年来随着分子医学研究的进展,发现基质金属蛋白酶(MMPs)、细胞凋亡与PPROM已具有相关性,现本文就PPROM影响因素研究进展进行综述。

Premature rupture of membranes （PPROM） is one of the common complications of obstetrics, which has a serious impact on maternal and infant health. It is also a common cause of fetal death. The cause of fetal death has not been determined. Domestic and foreign studies have found that it may be impacted by many factors such as maternal infection, injury, trace element deficiency, cervical function and fetal development. In recent years, with the progress of molecular medicine research, it found that matrix metalloproteinases （MMPs）, apoptosis and PPROM have a correlation. This article reviews the progress of PPROM.