肠道菌群与非酒精性脂肪肝相关性的研究进展

Correlation between intestinal flora and nonalcoholic fatty liver disease:a review on research progress

非酒精性脂肪肝(NAFLD)是我国最常见的慢性肝病之一,为非酒精性因素所致的肝细胞脂肪变为特征的综合征,包括单纯性脂肪肝(SFL)、非酒精性脂肪性肝炎(NASH)及其相关肝硬化和肝细胞癌(HCC)。人体肠道中的各种菌群发挥着不同的病理生理作用,与许多疾病密切相关,肠道菌群可以通过"肠-肝轴"影响NAFLD的发生发展,"二次打击"学说很好地解释了NAFLD的发病机制及其与肠道菌群的关系。益生元、益生菌可以很好地调节肠道菌群,与抗生素和手术相比更加廉价、无害、安全,有望成为预防和治疗NAFLD的新方法。本研究对肠道菌群与NAFLD相关性的研究进展加以综述。

Nonalcoholic fatty liver disease（NAFLD）is one of the most common chronic liver diseases in China.It is characterized by hepatic steatosis caused by nonalcoholic factors,including simple fatty liver（SFL）,nonalcoholic steatohepatitis（NASH）and related liver cirrhosis and hepatocellular carcinoma（HCC）.Intestinal flora plays an important role in the pathological and physiological progress of and associated with many diseases in human body.It contributes to the development and progression of NAFLD through ＂gut-liver axis＂,and the pathogenesis can be explained by ＂ two hits＂ theory.Comparing with antibiotics and surgery,prebiotics and probiotics are more cheap,harmless and safe;they can regulate intestinal flora effectively.It is expected to be a new method for prevention and treatment of NAFLD.This study reviews the progress in researches on the correlation between intestinal flora and NAFLD.