缬沙坦与依那普利治疗原发性高血压对肾功能影响的比较

Comparison of Valsartan and Enalapril on Kidney Function in Patients with Primary Hypertension

目的:选用缬沙坦和依那普利治疗原发性高血压,并通过监测治疗前后血压、肾功能等指标的变化,评价该疗法的有效性及安全性。方法:100例原发性高血压患者随机分成A、B两组,给予A组:缬沙坦80 mg/d,B组:依那普利10 mg/d。治疗前后监测血压、肾功能,治疗8周,观察临床疗效。结果:缬沙坦和依那普利均能有效的控制血压,能降低血、尿微球蛋白。结论:缬沙坦和依那普利治疗原发性高血压,不仅能有效的控制血压,而且能降低尿蛋白,保护肾功能,延缓肾功能不全的进展。若无明显禁忌缬沙坦可作为早期肾功能受损患者治疗高血压的首选药物。

Objective To treat the primary hypertension by applying valsartan or enalapril while monitoring the blood pressure, kidney function. To evaluate the effects and safety according to the result. Methods A total of 100 cases of hypertension patients were randomly divided into 2 groups, group A treated with valsartan, group B treated with enalapril. The curative effects in each group were observed after 8 weeks. Results Valsartan and enalapril could effectively control blood pressure and reduce blood microglobulin, urine microglobulin. Conclusion Not only valsartan and enalapril can effectively control blood pressure, but also can reduce urinary protein, protect renal function, delay the progress of renal dysfunction. Valsartan can be used as the first choice for the treatment of hypertension in patients with early renal impairment.