PF、GP及DC方案诱导化疗联合放疗局部晚期鼻咽癌的近期疗效比较

Clinical Therapeutic Study of Different Induction Chemotherapy with Radiotherapy on Advanced Nasopharygeal Carcinoma

目的：比较5-氟尿嘧啶联合铂类（PF）、吉西他滨联合铂类（GP）及多西他赛联合铂类（DC）3种方案诱导化疗联合放疗治疗局部晚期鼻咽癌的近期疗效。方法：68例II-IVA期病理确诊为鼻咽癌的患者分为3组,PF组16例,GP组30例,DC组22例。每组采用不同的诱导化疗的方法化疗2∽3程后予根治性放疗。结果：3组诱导化疗结束后及放疗后3月鼻咽及颈部淋巴结的缓解率比较,差异无统计学意义（P〉0.05）,毒副反应方面PF的III度及以上放射性口腔粘膜炎较其它两组稍高,但差异无统计学意义（P〉0.05）。结论：PF、GP及DC这3种方案诱导化疗联合放疗治疗局部晚期鼻咽癌可耐受且近期疗效相当,有待进一步临床观察。

Objective To compare the short-term effects of PF, GP and DC three options induction chemotherapy combined with radiotherapy for locally advanced nasopharyngeal carcinoma. Methods 68 patients with stage II-IVA patients with pathologically confirmed nasopharyngeal carcinoma were divided into three groups. Each group was treated with 2-3 cycles of corresponding induction chemotherapy followed by radical radiotherapy. Results These three treatment methods had no significant difference in the remission rate of nasopharyngeal tumor and lymph node after the end of chemotherapy and three months after radiotherapy. Conclusion PF, GP and DC three induction chemotherapy combined with radiotherapy for locally advanced nasopharyngeal carcinoma were quite tolerable and had similar short-term effects, pending further clinical observation.