左氧氟沙星用于耐多药肺结核治疗的临床研究

Clinical Study of Levofl oxacin in the Treatment of Multidrug-resistant Tuberculosis

目的:评价左氧氟沙星用于耐多药肺结核治疗的有效性和安全性。方法:选取2012年4月-2014年4月于我院就诊的耐多药肺结核患者94例,随机分为氧氟沙星组和左氧氟沙星组。观察两组痰菌阴转率、病灶吸收率及不良反应情况。结果:左氧氟沙星组痰菌转阴率为95.7%,较氧氟沙星组80.9%显著升高,差异有统计学意义(P<0.05);左氧氟沙星组的吸收率为93.6%,也较氧氟沙星组74.5%显著升高,差异有统计学意义(P<0.05);左氧氟沙星组的治疗总有效率为93.6%,较氧氟沙星组72.3%显著升高,差异具有统计学意义(P<0.05);氧氟沙星组不良反应发生率为29.8%,左氧氟沙星组不良反应发生率为12.8%,差异具有统计学意义(P<0.05)。结论:左氧氟沙星对于耐多药肺结核的疗效显著,且能减少不良反应的发生。

Objective To study clinical effi cacy and safety of levofl oxacin used for multidrug-resistant tuberculosis treatment. Methods 94 cases between April 2012 to April 2014 in our hospital were randomly divided into ofl oxacin group and levofl oxacin group, respectively adopt basic drug treatment combined ofl oxacin and levofl oxacin.Two groups＇ phlegm germ feminine changed rate, lesions absorption rate and adverse reactions were observed. Results Levofl oxacin group＇ sputum bacterium turns shade rate was 95.7 %, which showed a signifi cant rise in levofl oxacin group（80.9 %）; Levofl oxacin group absorption rate was 93.6 %, which also showed a signifi cant rise in levofl oxacin group（74.5 %）; The treatment of levofl oxacin group total effective rate was 93.6 %, a signifi cant rise in levofl oxacin group（72.3 %）; Levofl oxacin group the incidence of adverse reactions was signifi cantly lower than ofl oxacin（29.8 %）. Conclusion Levofl oxacin in the treatment of multi-drug resistant tuberculosis curative effect is distinct, and can reduce the occurrence of adverse reactions, can be widely used in clinic.