肠息肉和肠易激综合征患者血清过敏原特异性IgE抗体临床分析

Allergen Specific Serum IgE Antibody in Patients with Intestinal Polyp and Irritable Bowel Syndrome: A Clinical Analysis

背景:累及胃肠道的过敏性疾病主要是嗜酸细胞性胃肠炎,一些功能性胃肠病与过敏原亦存在关联。目前尚未明确肠息肉的发生是否与过敏因素有关。目的:探讨过敏因素与肠息肉和肠易激综合征(IBS)的关系。方法:收集2012年5月-2014年4月住院肠息肉患者60例、IBS患者35例和同期健康志愿者95名,采集血清样本,以欧蒙印迹法检测20种常见吸入性和食物性过敏原特异性IgE抗体。结果:肠息肉组、IBS组和两组总体血清过敏原特异性IgE抗体阳性率均显著高于对照组(56.67%、74.29%和63.16%对6.32%,P均<0.05),两组患者组间差异无统计学意义(P>0.05)。患者组血清尘螨组合、蟑螂、蟹、海鱼组合、淡水鱼组合、虾、鸡蛋白特异性IgE抗体阳性率显著高于对照组(P<0.05),以蟹、海鱼组合、尘螨组合为著。结论:过敏因素与肠息肉和IBS之间可能存在一定关联。

Background： Eosinophilic gastroenteritis is the most common gastrointestinal allergic disease,however,allergy also accounts for some gastrointestinal functional disorders. The correlation between allergic factor and intestinal polyp is not clarified. Aims： To investigate the correlation of allergic factor with intestinal polyp and irritable bowel syndrome（ IBS）.Methods： Ninety-five inpatients including 60 cases of intestinal polyp and 35 cases of IBS admitted from May 2012 to April2014 were recruited; 95 healthy volunteers were served as controls. Serum samples were collected to test specific IgE antibodies derived from 20 common inhalant and alimentary allergens by EUROIMMUN blotting test. Results： The positivity rates of allergen specific serum IgE antibodies in intestinal polyp group,IBS group and both two groups were56. 67%,74. 29% and 63. 16%,respectively,all were significantly higher than that in control group（ 6. 32%,P all 0. 05）,but no statistically significant difference was seen between intestinal polyp group and IBS group（ P〉0. 05）. In all the 20 allergens tested,the positivity rates of Dermatophagoides,roach,crab,sea fish,freshwater fish,shrimp,and egg albumin specific serum IgE antibodies were significantly higher in patients group than in control group（ P〈0. 05）,especially the crab,see fish and Dermatophagoides specific IgE antibodies. Conclusions： Allergic factor might have some association with intestinal polyp and IBS.