Toll样受体及其基因多态性与胃黏膜疾病相关性的研究进展

Advances in Study on Toll-like Receptors and its Gene Polymorphisms in Gastric Mucosal Diseases

胃黏膜疾病的发生、发展是一个复杂的多因素、多机制过程,不同个体对胃黏膜疾病的遗传易感性有一定差异。众多研究发现Toll样受体(TLRs)作为一类重要的模式识别受体,与多种胃黏膜疾病的发生、发展有着密切的联系。TLRs基因多态性可使其编码蛋白或相关信号转导途径发生改变,使个体对某些胃黏膜疾病呈现出不同的易感性,从而影响疾病的发生、发展和临床结局。本文就TLRs及其基因多态性与胃黏膜疾病的相关性作一综述。

The development and progress of gastric mucosal diseases is a complex process associated with multiple factors and underlying mechanisms,and individuals may present different genetic susceptibilities to gastric mucosal diseases. Various studies have demonstrated a strong link between Toll-like receptors（ TLRs）,as pattern recognition receptors,and the development and progress of gastric mucosal diseases. The gene polymorphisms of TLRs may change its encoded proteins or related signaling pathways,which results in different susceptibilities to gastric mucosal diseases; this might affect the development,progress and clinical outcome of the disease. In this review article,the advances in study on TLRs and its gene polymorphisms in gastric mucosal diseases were summarized.