NLRP3在自身免疫性疾病中的研究进展

Advances in Study on NLRP3 in Autoimmune Diseases

炎症小体是一种蛋白质复合体,可调节半胱天冬酶-1(caspase-1)活化,促进细胞因子产生,从而在免疫防御中发挥重要作用。NLRP3炎症小体是NOD样受体(NLR)家族的重要成员,其主要在巨噬细胞和树突细胞中激活并表达。NLRP3可感知病原相关分子模式(PAMPs)和损伤相关分子模式(DAMPs),启动先天性免疫应答,在自身免疫性疾病的发生、发展过程中发挥重要作用。本文就NLRP3在自身免疫性疾病中的研究进展作一综述。

Inflammasome is a multi-protein complex which plays an important role in innate immune defense,and can adjust the activation of caspase-1 and promote the production of cytokines. NLRP3 is an important member of inflammasome Nod-like receptor（ NLR） family,and its activation and expression occur mainly in macrophages and dendritic cells. NLRP3 can sense the pathogen associated molecular patterns（ PAMPs） and damage associated molecular patterns（ DAMPs） and initiate the inherent immune response,which plays an important role in the pathogenesis of autoimmune diseases. This article reviewed the advances in study on NLRP3 in autoimmune diseases.