不同剂量川芎嗪对兔背缺血皮瓣的作用

The effect of different dosages of ligustrazine on the ischemic skin flap of rabbit back

目的：寻找川芎嗪对缺血皮瓣发挥保护作用的合适剂量。方法：家兔16只随机分为4组,于兔背部设计8 cm×2 cm任意皮瓣,切取、剥离后原位缝合。对照组（A组）予以0.9%氯化钠注射液4 ml/kg,术后用药组分别予以川芎嗪15、30、60 mg/kg（B、C、D组）。术后第7天处死白兔,测量皮瓣成活面积,分析不同剂量的川芎嗪与皮瓣成活之间的关系。结果：术后第7天皮瓣远端均发生坏死,近端成活。随药物剂量增加,C、D组皮瓣成活面积及成活率均高于A、B组（P〈0.05-P〈0.01）;A组与B组和C组与D组皮瓣成活面积及成活率差异均无统计学意义（P〉0.05）。结论：适当剂量使用川芎嗪治疗可提高局部缺血皮瓣的成活率。

Objective： To investigate the suitable dosages of ligustrazine with good protective effect on ischemic skin flap. Methods：The Japanese big ear white rabbits were randomly divided into four groups. The 8 cm × 2 cm random flap in the rabbit back was designed,cut and stripped,and the rabbits were stitched in situ. Group B,C and D were treated with 15,30 and 60 mg / kg of ligustrazine after operation,respectively,and the group A were treatment with 4 ml / kg of 0. 9% sodium chloride injection. Rabbits were sacrificed after 7 days of operation,the flap survival area was measured,the relationship between different concentrations ligustrazine and flap survival was analyzed. Results： The distal necrosis and proximal survival of flap was found after days 7 operation. With the increasing of drug dosages,the flap survival area and average survival rate increased. The flap survival area and average survival in group C and D were higher than those in group A and B（ P〈0. 05 to P〈0. 01）,the differences of which between group A and B,and between group C and D were not statistically significant（ P〉0. 05）. Conclusions： Appropriate dose of ligustrazine can improve the survival rate of ischemic skin flap.