RASSF1 A 及其甲基化与乳腺癌的关系

RASSF1A and RASSF1A methylation′s relationship with breast cancer

乳腺癌是女性最常见的恶性肿瘤之一。早期诊断在乳腺癌的治疗中起着重要的作用。近年来随着表观遗传学的发展，为肿瘤的早期检测提供了新的方向。在表观遗传学中DNA甲基化与乳腺癌的关系的研究最为广泛，RASSF1A（ras相关区域家族基因1A）甲基化发生在乳腺癌的早期，与肿瘤的TNM分期、侵袭性以及预后有关。同时RASSF1A的甲基化是可逆的，因此RASSF1A甲基化的研究可为乳腺癌的早期诊断提供生物靶点，也为乳腺癌的治疗提供了一个潜在的研究方向。

Breast cancer is one of the most common malignant tumors in women.Early diagnosis plays a very important role in the treatment of breast cancer.Recently,with the development of epigenetics,it gives us a new orientation for early detection for cancers.The most understood mechanism of epigenetics is DNA methyla-tion.Ras associated domain family 1A gene（RASSFlA）promoter methylation occurres in tumor′s early stage,and have a statistically concern with tumor′s TNM stage,invasiveness and outcomes.Moreover,DNA methylation can be reversed,so RASSF1A can be a promising candidate for early breast cancer detection biomarker,and can be a potential orientation for breast cancer treatment.