生物代谢表型研究进展

Review on Metabotype

生物代谢表型的概念被广泛应用于药物代谢组学和营养基因组学中,并且为个人治疗提供新的研究方法。与模糊的代谢表型的概念不同,生物代谢表型有着明确的定义。生物代谢表型主要由生物体的基因组、肠道菌群、生活环境及外源物的摄入共同决定,并且可以用4个标准进行描述:代谢物的有无、代谢物的含量(浓度)、代谢物之间的比值及代谢概况。依据这4个标准所建立的模型在生物学研究中很有意义,作者在最后将这一模型应用于黄曲霉毒素B1的研究中,试图为该模型的应用提供新的思路。

Metabotype concept has been widely used in pharmacometabonomics and nutrigenomics,which also provides a new bioanalytical territory for personalized treatment. Different from the metabolic phenotype,metabotype has a clear definition. Metabotype is mainly determined by the genome,the intestinal flora,environment and the intakes,which can be described by four criteria,i.e.,metabolites,their concentrations,their ratios and the metabolic profiles. The model established via the four criteria,which is useful in the biological field,was applied to study Aflatoxins B1 in this paper,providing a new perspective for its application.