抗厌氧菌类抗生素耐药机制及其临床使用的研究进展

Research Progress on Resistant Mechanism of Anti-anaerobic Antibiotics and its Clinical Medication

厌氧菌是人体内正常菌群的主要组成部分,但同时也可引起人体多类内源性疾病的致病菌群。由于现代培养及分离条件的提高,针对厌氧致病菌的研究日益增多,而抗生素疗法作为主要的厌氧菌疾病治疗方法也进一步引起科学家和医药工作者的关注。与此同时,厌氧菌的耐药性逐渐增强,因此新抗生素的发现成为治疗厌氧菌感染的新目标。综述常用致病厌氧菌的耐药机制以及各类抗厌氧菌药物的使用文献资料,并对其研究进展做了分析。

Anaerobic bacteria are important constituents of the body normal flora,but can cause many kinds of endogenous disease pathogenic bacteria in human body. Because of improving modern culture and separation conditions,study on anaerobic pathogenic bacteria is increasing day by day. Antibiotic therapy as primary treatment of anaerobic bacteria disease, attracts a further attention from scientists and medical workers. At the same time, the resistance increases gradually, and the discovery of novel antibiotics becomes a new target for treating anaerobic bacteria infection.The of the literature of common pathogenic anaerobic bacteria, resistance mechanism and the clinical medication of all kinds of anti-anaerobic agents were reviewed, and the research progress was analyzed.