羟考酮与曲马多用于中度癌痛患者初始镇痛疗效的比较

Comparison of Initial Analgesic Efficacies of Oxycodone with Tramadol in Patients with Moderate Cancer Pain

目的:比较盐酸羟考酮缓释片与盐酸曲马多缓释片对中度癌痛患者初始镇痛疗效和安全性,为临床治疗癌痛患者提供参考。方法:选取中度癌痛患者60例,将其分为观察组(羟考酮组,30例)与对照组(曲马多组,30例);观察组患者给予口服盐酸羟考酮缓释片治疗,对照组患者给予口服盐酸曲马多缓释片治疗,治疗1周后比较两组患者用药的意愿、疼痛控制率、疼痛缓解时间、BPI评分值及药物不良反应等指标。结果:观察组患者在疼痛控制率、疼痛缓解时间、BPI评分值均优于对照组(P<0.05);致便秘不良反应的发生率前者为50.00%高于后者为16.67%(P<0.05)。结论:盐酸羟考酮缓释片用于治疗中度癌痛患者初始镇痛疗效和安全性优于盐酸曲马多缓释片。

Objective： To compare the initial analgesic efficacies and safety of oxycodone hydrochloride sustainedrelease tablet and tramadol hydrochloride sustained-release tablet in patients with moderate cancer pain and to provide a reference for clinical medication of patients with cancer pain. Methods：Selecting 60 patients with moderate cancer pain, they were divided into observation group（oxycodone group, n=30） and control group（tramadol group, n=30）. Observation group patients were given sustained-release tablet treatment and control group patients were given oral tramad-ol hydrochloride sustained-release tablet treatment. To compare the will of use drug, the rate of pain control, the time of pain relief, the score values of BPI and ADR after 7 days of treatment. Results：Observation group patients in the control of cancer pain, the time of pain relief, BPI score values were better than those of control group（P〈0.05）. The incidence of ADR caused by constipation of the former was 16.67% lower than the latter 50.00%（P〈0.05）. Conclusion： Initial analgesic efficacy and safety of Oxycodone hydrochloride sustained-release tablet for the treatment of patients with moderate cancer pain is better than that of tramadol hydrochloride sustained-release tablet.