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The neuroprotective effects of human growth hormone as a potential treatment for amyotrophic lateral sclerosis

The neuroprotective effects of human growth hormone as a potential treatment for amyotrophic lateral sclerosis
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摘要 Human growth hormone(GH)is a single-chain polypeptide of 191 amino acids that is involved in the regulation of various physiological processes,such as growth and metabolism.GH is synthesized and secreted by somatotropic cells in the anterior pituitary gland.Its secretion is primarily regulated by a balance between growth hormone-releasing hormone and growth hormone-inhibiting hormone, Human growth hormone(GH)is a single-chain polypeptide of 191 amino acids that is involved in the regulation of various physiological processes,such as growth and metabolism.GH is synthesized and secreted by somatotropic cells in the anterior pituitary gland.Its secretion is primarily regulated by a balance between growth hormone-releasing hormone and growth hormone-inhibiting hormone,
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第8期1201-1203,共3页 中国神经再生研究(英文版)
基金 supported by grants from the Korea Health 21 R&D Project(HI14C2348) the National Research Foundation of Korea(NRF2014R1A2A1A11051520)
关键词 amyotrophic metabolism secretion physiological inhibiting secreted neuronal primarily pituitary polypeptide amyotrophic metabolism secretion physiological inhibiting secreted neuronal primarily pituitary polypeptide
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  • 1Aberg MA, Aberg ND, Hedbacker H, Oscarsson J, Eriksson PS (2000) Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus. J Neurosci 20:2896-2903.
  • 2Aberg ND, Brywe KG, Isgaard J (2006) Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. ScientificWorldJournal 6:53-80.
  • 3Arce VM, Devesa P, Devesa J (2013) Role of growth hormone (GH) in the treatment on neural diseases: from neuroprotection to neural repair. Neurosci Res 76:179-186.
  • 4Azcoitia I, Perez-Martin M, Salazar V, Castillo C, Ariznavarreta C, Gar-cia-Segura LM, Tresguerres JA (2005) Growth hormone prevents neuronal loss in the aged rat hippocampus. Neurobiol Aging 26:697-703.
  • 5Chung JY, Kim HJ, Kim M (2015) The protective effect of growth hormone on Cu/Zn superoxide dismutase-mutant motor neurons. BMC Neurosci 16:1.
  • 6Dodge JC, Treleaven CM, Fidler JA, Hester M, Haidet A, Handy C, Rao M, Eagle A, Matthews JC, Taksir TV, Cheng SH, Shihabuddin LS, Kaspar BK (2010) AAV4-mediated expression of IGF-1 and VEGF within cellular components of the ventricular system improves survival outcome in familial ALS mice. Mol Ther 18:2075-2084.
  • 7Herrington J, Carter-Su C (2001) Signaling pathways activated by the growth hormone receptor. Trends Endocrinol Metab 12:252-257.
  • 8Herrington J, Smit LS, Schwartz J, Carter-Su C (2000) The role of STAT proteins in growth hormone signaling. Oncogene 19:2585-2597.
  • 9Kaspar BK, Frost LM, Christian L, Umapathi P, Gage FH (2005) Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. Ann Neurol 57:649-655.
  • 10Li RC, Guo SZ, Raccurt M, Moudilou E, Morel G, Brittian KR, Gozal D (2011) Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats. Neuroscience 196:237-250.

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