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Fractalkine: multiple strategies to counteract glutamate receptors activation leading to neuroprotection 被引量：2

Fractalkine: multiple strategies to counteract glutamate receptors activation leading to neuroprotection
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摘要 Glutamate（Glu）is the main excitatory amino acid in the brain and plays a pivotal role in many neurophysiological functions.Nevertheless,an excess and prolonged exposure to Glu determines the overactivation of glutamate receptors（Glu Rs）with consequent impairment of cellular calcium（Ca2＋）homeostasis, Glutamate（Glu）is the main excitatory amino acid in the brain and plays a pivotal role in many neurophysiological functions.Nevertheless,an excess and prolonged exposure to Glu determines the overactivation of glutamate receptors（Glu Rs）with consequent impairment of cellular calcium（Ca2＋）homeostasis,
作者 Clotilde Lauro
机构地区 Department of Physiology and Pharmacology
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第8期1214-1215,共2页 中国神经再生研究（英文版）
关键词 glutamate excitatory impairment homeostasis neuronal Glutamate NMDAR intracellular adenosine microglia glutamate excitatory impairment homeostasis neuronal Glutamate NMDAR intracellular adenosine microglia
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献11

  • 1Cardona AE, Pioro EP, Sasse ME, Kostenko V, Cardona SM, Dijkstra IM, Huang D, Kidd G, Dombrowski S, Dutta R, Lee JC, Cook DN, Jung S, Lira SA, Littman DR, Ransohoff RM (2006) Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 9:917-924.
  • 2Catalano M, Lauro C, Cipriani R, Chece G, Ponzetta A, DiAngelantonio S, Ragozzino D, Limatola C (2013) CX3CL1 protects neurons against ex-citotoxicity enhancing GLT-lactivity on astrocytes. J Neuroimmunol 263:75-82.
  • 3Chapman GA, Moores K, Harrison D, Campbell CA, Stewart BR, Strijbos PJ (2000) Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage. J Neurosci 20:RC87.
  • 4Cipriani R, Villa P, Chece G, Lauro C, Paladini A, Micotti E, Perego C, De Simoni MG, Fredholm BB, Eusebi F, Limatola C (2011) CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents. J Neurosci 31:16327-16335.
  • 5Hardingham GE, Bading H (2010). Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat Rev Neurosci 11:682-696.
  • 6Harrison JK, Jiang Y, Chen S, Xia Y, Maciejewski D, McNamara RK, Streit WJ, Salafranca MN, Adhikari S, Thompson DA, Botti P, Bacon KB, Feng L (1998) Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci U S A 95:10896-10901.
  • 7Lauro C, Cipriani R, Catalano M, Trettel F, Chece G, Brusadin V, An-tonilli L, van Rooijen N, Eusebi F, Fredholm BB, Limatola C (2010) Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death. Neuropsychopharmacology 35:1550-1559.
  • 8Lauro C, Di Angelantonio S, Cipriani R, Sobrero F, Antonilli L, Brusadin V, Ragozzino D, Limatola C (2008) Activity of adenosine receptors type 1 is required for CX3CL-mediated neuroprotection and neuromodula-tion in hippocampal neurons. J Immunol 180:7590-7596.
  • 9Rosito M, Deflorio C, Limatola C, Trettel F (2012) CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS. J Neurosci 32:3154-3163.
  • 10Rosito M, Lauro C, Chece G, Porzia A, Monaco L, Mainiero F (2014) Trasmembrane chemokines CX3CL1 and CXCL16 drive interplay between neurons, microglia and astrocytes to counteract pMCAO and excitotoxic neuronal death. Front Cell Neurosci 8:193.

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Neural Regeneration Research
2015年 第8期

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