皮肤磨削术联合外用重组人碱性成纤维细胞生长因子修复表浅性瘢痕的疗效观察

Observation on the Efficacy of Skin Grinding Combined with External Application of Recombinant Human Basic Fibroblast Growth Factor in the Treatment of Superficial Scars

目的 探讨皮肤磨削术联合外用重组人碱性成纤维细胞生长因子（Recombinant human basic fibroblast growth factor,rh-b FGF）治疗表浅性瘢痕的临床疗效。方法 2010年2月至2015年3月,对23例表浅性瘢痕患者采用皮肤磨削术治疗,并给予附有rh-b FGF溶液的凡士林纱布覆盖创面,加压包扎。术后随访并进行疗效评价。结果 本组23例中,疗效显著18例,有效3例,无效2例,有效率90.9%;随访1~8个月,患者术后出现不同程度的红斑和色素沉着,经积极护理和治疗,均得到满意效果。结论 皮肤磨削术联合外用rh-b FGF修复表浅性瘢痕疗效可靠,可缩短创面愈合时间,同时可有效抑制新的瘢痕组织的形成。

Objective To explore the clinical efficacy of skin grinding combining with external application of recombinant human basic fibroblast growth factor （rh-bFGF） in the treatment of superficial scar. Methods From February 2010 to March 2015, 23 patients with superficial scar were treated with dermabrasion, then the wound was covered with vaseline gauze that accompanied by rh-bFGF solution, and bandaged. Follow-up and curative effect evaluation were carried out after operation. Results After treatment, markedly effective results were observed in 18 cases, effective results were observed in 3 cases, ineffective results were observed in 2 cases, and the effective rate was 90.9%. All the patients were followed up for 1 to 8 months. The wound showed different degree of erythema and pigmentation after operation, and all of them obtained satisfactory results through active nursing and treatment. Conclusion Skin grinding combining with external application of rh-bFGF can reduce the time of wound healing and inhibit the formation of scar tissue, the curative effect is reliable.