缺血性心力衰竭患者尿酸相关性因素分析

Relevant factors of uric acid in patients with ischemic heart failure

目的分析缺血性心力衰竭患者尿酸的相关性因素。方法连续选取缺血性心力衰竭、纽约心脏协会心功能分级Ⅱ~Ⅲ级住院患者88例,测量其尿酸浓度。采用单变量相关分析确定单变量相关因素,采用逐步多元线性回归分析确定其独立相关性因素。结果无高血压病史组尿酸明显低于高血压病史组,差异有统计学意义[（394.63±135.12）μmmol/L vs.（467.39±143.89）μmmol/L,P=0.017]。总胆固醇、肌酐、脑钠肽与尿酸单变量相关（r=0.240、0.502、0.300;P=0.029、0.000、0.300）。尿酸与总胆固醇、肌酐独立相关（β=23.152、1.452,P=0.030、0.004）。结论总胆固醇、肌酐是尿酸的独立相关因素。

Objectives To determine the relevant factors of uric acid in patients with ischemic heart failure（IHF）.Methods Totally 88 admitted IHF patients with New York Heart Association Class II-III were selected. Serum concentrations of uric acid of these patients were detected. Univariate regression analysis was used to confirm the relevant factors of uric acid and stepwise multiple linear regression analysis was used to confirm the independent relevant factors. Results Serum concentration of uric acid in patients without hypertension history was significantly lower than that in patients with hypertension history [（394.63±135.12） μmmol / L vs.（467.39±143.89） μmmol / L, P=0.017 ]. Univariate regression analysis showed that total cholesterol, creatinine and brain natriuretic peptide correlated with uric acid（r=0.240, 0.502, 0.300; P=0.029, 0.000, 0.300）. Stepwise multiple linear regression analysis showed that total cholesterol and creatinine independently related with uric acid（β =23.152,1.452;P =0.030,0.004）.Conclusions Total cholesterol and creatinine are the independent factors of uric acid.