肺炎支原体患儿血清IL-6与瘦素的检测及其临床意义

Detection and Clinical Significance of Serum IL-6 and Leptin in Children with Mycoplasma Pneumonia

目的探讨检测支原体肺炎(MPP)患儿血清细胞因子白介素-6(IL-6)与瘦素的临床意义。方法 50例MPP患儿(病例组)和50例健康儿童(对照组)为研究对象,分别采用放射免疫法测定血清瘦素,酶联免疫吸附试验检测(IL-6)水平。结果病例组(急性期、恢复期)血清IL-6、瘦素水平均高于正常对照组(P<0.05);急性期与正常对照组比较差异尤为显著。结论血清IL-6与瘦素参与了MPP发生和进展,它们在MP感染中起着重要作用,检测这两个指标对病情的评估有一定的临床使用价值,为小儿MPP的治疗指出了新的方向。

Objective Study on detection of mycoplasma pneumonia（MPP） patients serum cytokine interleukin-6（IL-6） and the clinical significance of leptin.Methods 50 patients with MPP（case group） and 50 healthy children（control group） were studied by radioimmunoassay. Serum leptin was measured by radioimmunoassay（IL-6）.Results The levels of serum IL-6 and leptin in the patients（acute stage and recovery stage） were significantly higher than those in the normal control group（P〈0.05）.Conclusions Serum IL-6 and leptin were involved in the development and progression of MPP. They played an important role in MP infection. These two indexes were used to evaluate the clinical value of MPP.