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肾上腺素受体基因多态性与青光眼患者眼压的关系研究进展 被引量:1

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摘要 肾上腺素受体(AR)广泛存在于内眼组织,被认为与房水的生成及眼压昼夜节律的形成有关。AR存在基因多态性,与青光眼患者眼压相关的AR基因多态性位点有α2B-AR的Del 301-303(I/D),α2C-AR的Del 322-325(I/D),β1-AR的S49G(A/G)、R389G(C/G),β2-AR的R16G(A/G)、Q27E(C/G),且其亦与临床多种疾病有关。
作者 高延琳
机构地区 天津市眼科医院
出处 《山东医药》 CAS 北大核心 2015年第31期99-101,共3页 Shandong Medical Journal
基金 天津市自然科学基金资助项目(13JCYBJC39900)
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  • 1Gregory DS.Timolol reduces IOP in normal NZW rabbits during the dark only[J].Invest Ophthalmol Vis Sci,1990,31(4):715-721.
  • 2Liu JH,Dacus AC,Bartels SP.Adrenergic mechanism in circadian elevation of intraocular pressure in rabbits[J].Invest Ophthalmol Vis Sci,1991,32(8):2178-2183.
  • 3Bhmer T,Manicam C,Steege A,et al.TheαB-adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium[J].Br J Pharmacol,2014,171(16):3858-3867.
  • 4Huang Y,Gil DW,Vanscheeuwijck P,et al.Localization of alpha2-adrenergic receptor subtypes in the anterior segment of the human eye with selective antibodies[J].Invest Ophthalmol Vis Sci,1995,36(13):2729-2739.
  • 5Bylund DB,Chacko DM.Characterization of alpha2 adrenergic receptor subtypes in human ocular tissue homogenates[J].Invest Ophthalmol Vis Sci,1999,40(10):2299-2306.
  • 6Woldemussie E,Wijono M,Pow D.Localization of alpha 2 receptors in ocular tissues[J].Vis Neurosci,2007,24(5):745-756.
  • 7Wax MB,Molinoff PB.Distribution and properties of beta-adrenergic receptors in human iris-ciliary body[J].Invest Ophthalmol Vis Sci,1987,28(3):420-430.
  • 8Feher J,Pescosolido N,Tranquilli Leali FM,et al.Microvessels of the human optic nerve head:ultrastructural and radioreceptorial changes in eyes with increased IOP[J].Can J Ophthalmol,2005,40(4):492-498.
  • 9Mantyh PW,Rogers SD,Allen CJ,et al.Beta 2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat,rabbit,and human[J].J Neurosci,1995,15(1 Pt 1):152-164.
  • 10Schwartz SG,Puckett BJ,Allen RC,et al.Beta1-adrenergic receptor polymorphisms and clinical efficacy of betaxolol hydrochloride in normal volunteers[J].Ophthalmology,2005,112(12):2131-2136.

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