胃癌新辅助治疗研究进展

Advances in neoadjuvant treatment for gastric cancer

胃癌D2根治性手术,被认为是治疗胃癌的主要手段。但在我国胃癌患者确诊时一般已是进展期,导致行根治性切除后复发率很高。为进一步改善进展期胃癌患者根治性切除术的预后,新辅助治疗应用于进展期胃癌患者的治疗并取得了一系列积极成果。本文将讨论新辅助治疗的概念,并基于目前循证医学证据提出治疗建议。

Surgery is still considered to be the mainstay for the treatment of gastric cancer with negative margins and D2-lymphadenectomy. However, in our country, most cases with confirmed gastric cancer are already at advanced stage, which may lead to high recurrences after radical resection. In order to improve prognosis after curative resection, neoadjuvant treatment is applied in patients with locally advanced tumors and it has achieved some positive results. In this article, we discuss the concept of neoadjuvant treatment approach and provide some treatment recommendations based on current evidence.