阻塞性睡眠呼吸暂停综合征患者血管内皮生长因子与右心室舒张功能的关系

Relationship between Vascular Endothelial Growth Factor and Right Ventricular Diastolic Function in Patients with Obstructive Sleep Apnea Syndrome

目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者血清中血管内皮生长因子(VEGF)的变化以及与右心室舒张功能的关系。方法对OSAS患者(42例,OSAS组)和正常体检者(42例,对照组)进行多导睡眠图(poly somnography,PSG)监测和血清VEGF含量的检测,并用二维多普勒超声心动图测定2组的右心功能。结果 OSAS组患者血清VEGF含量升高,明显高于对照组(P<0.01)。OSAS患者右心室搏出量(RVSV)较对照组增大(P<0.01),而右心室E/A值较对照组减小(P<0.01)。OSAS患者血清VEGF与右心室E/A呈负相关关系(r=-0.37,P<0.01)。结论 OSAS患者血清VEGF含量明显增高,与OSAS患者右心功能不全有关。

Objective To investigate the changes in serum levels of vascular endothelial growth factor（VEGF）and its relationship to right ventricular diastolic function in patients with obstructive sleep apnea syndrome（OSAS）.Methods Polysomnography was performed and serum VEGF levels were measured in 42 OSAS patients（OSAS group）and 42 normal subjects（control group）.In addition,the right ventricular function was determined using two-dimensional echocardiography in both groups.Results Compared with control group,serum VEGF levels and right ventricular stroke volume significantly increased but E/A ratio obviously decreased in OSAS group（P〈0.01）.There was a negative correlation between serum VEGF levels and right ventricular E/A ratio（r=-0.37,P〈0.01）.Conclusion Serum VEGF levels significantly increase and are correlated with right heart dysfunction in OSAS patients.