共信号分子B7-H4在人肺腺癌中的表达及临床意义

The expression and its clinical significance of B7-H4 in human pulmonary adenocarcinoma

目的研究共信号分子B7-H4在人肺腺癌组织中的表达及临床意义。方法收集2013年10月-2014年10月手术切除的肺腺癌患者肺癌组织标本94份,正常肺组织标本20份,应用免疫组织化学法,分别检测组织标本中B7-H4的表达水平。结果 B7-H4在20份正常人肺组织中表达较低,在94份人肺腺癌组织中的阳性表达率为67.32%,在合并有淋巴结转移的肺腺癌组织中B7-H4的阳性表达率为73.24%。低分化组肺腺癌组织B7-H4阳性表达率(84.82%)明显高于中分化组(77.38%)和高分化组(62.51%)。结论共信号分子B7-H4在肺腺癌组织中表达上调,有可能成为评价肺腺癌分化程度和淋巴结转移的指标之一。

Objective To study the expression and its clinical significance of signal molecule B7-H4 in hu- man pulmonary adenocarcinoma tissues. Methods 94 tissue samples of human pulmonary adenoearcinoma and 20 normal lung tissues were collected during Oct. 2013 to Oct. 2014. The expression of BT-H4 in lung tissues was identi- fied by immune histochemistry. Results The expression of BT-H4 was lower in 20 normal lung tissue, while its posi- tive expression rate was 67.32% in 94 tissue samples of pulmonary adenocarcinoma, and 73.24% in samples com- bined with metastasis of lymph nodes. The positive expression rate of BT-H4 was higher in poorly differentiated group （84. 82% ） than that in the middle （77. 38% ） and high differentiation group （62. 51% ）. Conclusion The expression of BT-H4 is up-regulated in tissues of pulmonary adnocarcinoma, and it might be one of the potential biomarkers for the evaluation of stage differentiation and metastasis of human pulmonary adenocarcinoma.